Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0002800 | Exon-Exon | chr21:38459547-38536517 | chr21:37087247-37164215 | 250 nt | 0.3360 |
| hsa_TTC3_0005400 | Exon-Exon | chr21:38460133-38575408 | chr21:37087833-37203107 | 250 nt | 0.2680 |
| hsa_TTC3_0006000 | Exon-Exon | chr21:38460496-38463713 | chr21:37088196-37091413 | 414 nt | 0.3454 |
| hsa_TTC3_0006100 | Exon-Exon | chr21:38460496-38498443 | chr21:37088196-37126143 | 1110 nt | 0.3658 |
| hsa_TTC3_0006800 | Exon-Exon | chr21:38461099-38519903 | chr21:37088799-37147603 | 1678 nt | 0.3766 |
| hsa_TTC3_0006900 | Exon-Exon | chr21:38461099-38529208 | chr21:37088799-37156906 | 2654 nt | 0.3723 |
| hsa_TTC3_0007200 | Exon-Exon | chr21:38463593-38501363 | chr21:37091293-37129063 | 878 nt | 0.3667 |
| hsa_TTC3_0008200 | Exon-Exon | chr21:38467650-38468943 | chr21:37095350-37096643 | 158 nt | 0.3418 |
| hsa_TTC3_0008300 | Exon-Exon | chr21:38467650-38507814 | chr21:37095350-37135514 | 891 nt | 0.3895 |
| hsa_TTC3_0009300 | Intron-Intron | chr21:38469021-38469206 | chr21:37096721-37096906 | 186 nt | 0.3495 |
Showing 11 to 20 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].