Basic Information

Symbol
AGER
RNA class
mRNA
Alias
Advanced Glycosylation End-Product Specific Receptor RAGE SCARJ1 SRAGE Advanced Glycosylation End Product-Specific Receptor Receptor For Advanced Glycation End-Products Receptor For Advanced Glycosylation End Products
Location (GRCh38)
6:32180963-32184344
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Postmortem interval inference Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001136.5
Sequence length
1420.0 nt
GC content
0.5923

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-580.70 kcal/mol
Thermodynamic ensemble
Free energy: -604.55 kcal/mol
Frequency: 0.0000
Diversity: 311.01
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.(((((((.((((....(((...(((....((((......))))..)))...))))))).))))..))).))))(((((((((.((.((((.........((((..((((((((..(((....))))))).))))..))))...(((((((................(.(((((((((((....((....))(((((.((((...(((((.((((((((((((...((((((((((((..(((((.((...(((....))))))))))..))))(((((.(((((((........)))...)))).)))))........(((((((((.......((....)).........(((((((((.(((..(((((((.((((((..((((.((((....)))).)))))))))).)(.(((((((.(.(((.....(((((((((......)))))))))))).)))))))).).((......))..)))))).))).))).))))))..((....)))))))))))......((((((.((((((((......)))))..(((..((((((((.(.(((((..(((((((.....(((((.(...(((((..((((((..((((((.....))))))..(((((((((......((((((.(((((((..((((.(((((.((((..((.((...))...))....)))).))))).)))))))((.((((((...)))))).))..))).).)))))).)))))))))(((....))).)))).)).)))))...)))))).))))))).)))))).))).....((((...((((...))))..)))).)))))..))))))))))))....((((.....)))).)))))))))))))))))))).....)))))..........)))).)))))..))))))))))).))))))))((((((((.((((((.......))))))..........(((((((.((((.....((((((((((..((((...(((((((((((.........)))))))))))...)))).)))).(((.((....((((((.(((.(((.(((....))).))))))..))))))....)).)))(.((((((((.(((((..((((...((((.(((((((((((((........((((...)))).((((....((((((..((.((.....((.(((..((((((....)))))).)))))...))))..)).))))))))))))))))))))))))).....))))))))).........)))))))).)...........))))))...)))).)))))))..)))))))))))).))....)))))))))...((((.(((......)))..))))...
Thermodynamic Ensemble Prediction
{(((.(((((((.((((....{({...(({....((((......))))..)))...))))))).)))),.))).)))|(((((((((.((.(({{.,,,.....((((..((((((((..(((....))))))).))))..))))...(((((((................(.(((((((((((....{(....)}(((((.((((...(((((.((((((((((({..,((((((((((({,{((((,,{{.,.(({,,.,}||{{|||||..,||{(((((,(({(((((,...,)))))...||||,}||||{.,{{(((((((((((,,........{|..||{...,,...|||{{|||{.{{{..((((((,,((((((..((((.((((....)))).)))))))))}.}{.(((((({,(.(((,....(((((((((......)))))))))))).)))))))).).({......)),.)))))).}}),)))})))}}}.,||}}}})))))})),))}...|,|{||||,||,,{||{,,,,,,))))),}(((,{(,,,{(((.(.(((((..(((((((.....(((((.(.,.(((((..((((((..((((((.....))))))..{((((((((..,,..((((((.(((((((..((((.(((((.((((..,(.{,...}}...}}....)))).))))).))))))))}.||{{{{,..)))))){|,..,)).).))))))}))))))))|(((....))),)))).)).)))))..,,))))).))))))).)))))},)))...}}||||...,{{{...)}}}{{|||,.||||,..,,,)))))))))..,,|||{...,.)))}.)))))))))))))))))))).....))}}}..........)))).)))))..))))))))))).)))))))),(((((((.((((((.......))))))..........(((((((.((((....{(,(((((({{.,((((...(((((((((((....,,,,}))))))))))}...})))}})}}})))),|}...((((((.(((.(((.(((....))).))))))..))))))....},.(((((((((((((.(((({.,((((...((((.((((((((((((({,.{,.,..(((..(({({{,..,},..||||..}}}{,,,,....((.(((..((((((....)))))).)))))...}},,..},.,},))))}))))))))))))))))).....))))))))).........}))))))}.......,,}}))))),,....)))).)))))))..)))))))}}}}}.}}....))))))))),..((((.{{,......}},..))))...

Transcripts

ID Sequence Length GC content
NM_001136.5 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1420 nt 0.5923
NM_001206929.2 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1468 nt 0.5892
NM_001206932.2 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1378 nt 0.5922
NM_001206934.2 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1423 nt 0.5777
NM_001206936.2 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1323 nt 0.5775
NM_001206940.2 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1375 nt 0.5804
NM_001206954.2 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1233 nt 0.5734
NM_001206966.2 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1277 nt 0.5803
NM_172197.3 NCBI
AGACAGAGCCAGGACCCUGGAAGGAAGCAGGAUGGCUGCCGGAACAGCA… 1265 nt 0.5881
Summary

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

Forensic Context

A study in humans demonstrated that the AGER mRNA in salivary extracellular vesicles is significantly upregulated in emergency department patients with acute head trauma compared to healthy controls (p=0.0203) and shows a significant expression difference between acute and outpatient concussion clinic patients (p=0.0243) [Cheng et al. DOI:10.1002/jcp.28139]. A study in rats demonstrated that the AGER is a potential biomarker for estimating the postmortem interval (PMI) after drowning, as its mRNA and secretory protein (sRAGE) levels in lung tissue, which were initially 12-fold higher than controls, showed a significant logarithmic decrease over a 7-day period [Cho & Eom DOI:10.1111/1556-4029.14063]. Another study in rats found the AGER serves as a diagnostic biomarker for drowning, with its mRNA and protein expression significantly elevated in drowned lungs compared to controls, hypoxia, and postmortem-submersion groups, and localized in type I alveolar epithelial cells [Lee et al. DOI:10.1016/J.Jflm.2019.01.007].