Basic Information

Symbol
CD27
RNA class
mRNA
Alias
CD27 Molecule CD27 Antigen TNFRSF7 S152 Tp55 Tumor Necrosis Factor Receptor Superfamily, Member 7 T-Cell Activation Antigen CD27 CD27L Receptor T14 Tumor Necrosis Factor Receptor Superfamily Member 7 T-Cell Activation Antigen S152 T Cell Activation Antigen S152 S152. LPFS2
Location (GRCh38)
12:6444941-6451718
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001242.5
Sequence length
1245.0 nt
GC content
0.5928

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-484.30 kcal/mol
Thermodynamic ensemble
Free energy: -502.88 kcal/mol
Frequency: 0.0000
Diversity: 211.73
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......((((((((.((........))))))..(((((..((((((.(((.(((.((((..(((((((......).))))))...((((((((((((((((......(((((..((..((..(((.((((((((.........((((((((((.......))))))))))(((((((((...((((.(.((((...)))).).)))).)))).)))))))))))).).))).))..(((((((((((....((((((((((((...(((((..((((.((((((...(((((.((....((((((.......((((((..((((....(((.......(((((((((............))))......))))).......).))..)))).)))).))......))))))...)).)))))....(((.......))).......)))))).)))))))))....))))))))))))(((..((((..((((...))))..))))..)))....(((..(.(((((....))))).)..))))))))))))))....))..)))))..((((.((.....)).)))).)))))))).((((((((.(((((((((...((((...(((.(((....))).))))))).))))))).)).))........))))))......((((((...((...))...))))))..(((((....)))))...)))))))).)))).))).))).))))))(((((((((.((((((((.(......).))))...)))).........((((.....))))((((..(((((((.....(((....)))((((.(.(((((.((((..(((((((...((((((.....)).))))..(((.....))).).)))))).))))))))).).))))..)))))))..))))......)))))))))......(((((((((((...(((((((((..........))).((((......)))).(((((..(((((((..(((((.((...((((.........)))))).)))))..)))))..))..)))))...........)))))).))))).).))))).((((((((..(((((((..((.(((((.((.....)).))))).)).)))))))..........))))))))((.............))........)))))................))))...
Thermodynamic Ensemble Prediction
.......((((((({{({.....,..))}}}}.,{((((,,((((((.(((.(((.((((.,,(,(((({{.{{{..|{||||..{(,,,,|||,,||||||..}}}}}||||.,,{,..(({((,.{{((,(((({{{.....((((((((((.......))))))))))(((((((((...((((.(.((((...)))).).)))).))))},))))||||,,,.,.))),....(((((((((((....((((((((((((...(((((..((((.((((((...(((((.((....((((((.,,,,..,(((((..((((,,,,{,{{{{,,..(((((((((............))))......)))))......,},)}}}))}),)))).)),.....))))))...)).)))))....(((.......})}...,),.)))))).)))))))))....))))))))))))(((..((((..((((...))))..))))..)))....(((..{.(((((....))))).}..))))))))))))))....,|{{||,,...((((.((.....)).)))).).,))))).((((((((.(((((((((...((((...(((.(((....))).))))))).))))))).)).))........))))))......,,|,||}}}|},}}))}}},,,},...(((((....))))).,,,,,}}))}.)))).))).))).))))))(((((((((.{(((((((.(......).)))),..}}}}.........((((.....))))((((..(((((((.....(((....)))((((.(.(((((.((((.{(((((((...((((((.....)).))))..(((.....))).),}))))).))))))))).).))))..)))))))..))))}.....)))))))))......(((((((((((...(((((((((..........))).((((......)))).(((((..(((((((..(((((.((.,,{(((....,,,.,)})))).)))))..)))))..))..)))))...........)))))).))))).).))))).((((((((..(((((((..((.(((((.((.....)).))))).)).)))))))..........)))))))){{,...........,}}........))))).......,|,......,}})...

Transcripts

ID Sequence Length GC content
NM_001242.5 NCBI
CUUCAAAGGUUGGCUUGCCACCUGAAGCAGCCACUGCCCAGGGGGUGCA… 1245 nt 0.5928
NM_001413263.1 NCBI
CUUCAAAGGUUGGCUUGCCACCUGAAGCAGCCACUGCCCAGGGGGUGCA… 1338 nt 0.5807
NM_001413264.1 NCBI
CUUCAAAGGUUGGCUUGCCACCUGAAGCAGCCACUGCCCAGGGGGUGCA… 1218 nt 0.5936
NM_001413265.1 NCBI
CUUCAAAGGUUGGCUUGCCACCUGAAGCAGCCACUGCCCAGGGGGUGCA… 1065 nt 0.5934
NM_001413266.1 NCBI
GUUGCUGAGGAAAGAGUGGAGGAGGCUGUUGACCCGUGUGUGUCCCCAU… 1196 nt 0.5686
NM_001413267.1 NCBI
GUUGCUGAGGAAAGAGUGGAGGAGGCUGUUGACCCGUGUGUGUCCCCAU… 1284 nt 0.5576
NM_001413268.1 NCBI
CAGAGUGUGACAGAAGAGAGGCAGCUCUACACCCCUUGCUUGCAAUUCU… 1321 nt 0.5435
Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the CD27 as a core diagnostic and prognostic biomarker for sepsis, with its highest odds and hazard ratios indicating a strong association with clinically overt sepsis [Li et al. DOI:10.3389/fimmu.2025.1700704]. Its expression was localized to T cells, and its diagnostic performance was validated across seven machine-learning models, achieving area under the curve values exceeding 0.9, though its expression did not show a statistically significant correlation with survival rate in the analysis performed.