Basic Information

Symbol
CD63
RNA class
mRNA
Alias
CD63 Molecule TSPAN30 Pltgp40 HOP-26 ME491 MLA1 AD1 Ocular Melanoma-Associated Antigen CD63 Antigen (Melanoma 1 Antigen) Melanoma-Associated Antigen ME491 Tetraspanin-30 Granulophysin CD63 Antigen AD1 Antigen Tspan-30 OMA81H Limp1 Lysosomal-Associated Membrane Protein 3 Lysosome Integral Membrane Protein 1 Melanoma-Associated Antigen MLA1 LAMP-3
Location (GRCh38)
12:55723511-55730023
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001780.6
Sequence length
1023.0 nt
GC content
0.5200

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-385.00 kcal/mol
Thermodynamic ensemble
Free energy: -405.65 kcal/mol
Frequency: 0.0000
Diversity: 210.04
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((((((((((.(.((((((((((...(((.(((((((((((((((...(.(((((((.(((((((((((((.(.((((((............)))))).))))))(((((.((((.((((....).)))...)))).)))))....)))))))).))))))).)...)))..)))))))...((((((....((((((((((....))))))))))......))))))......))..))).))).))))))))))).))))).)))).))))).)).(((.(((((((((((((.(((...((((((.(((((.((.(((((..((((((((((.(((.(((((.((((((((((((((.....))).)))).(((..(((((((((......))))....)))))..)))))))))).))))))))))))).....................((((((..(((((....)))))..))))))((((((((.((((((.((((((((.((((((((((((((((.......)))))).)))......((.(((((((((((.((.((((((((((.((((........)))).))))..(((.....)))(((..(((....)))..))))))))))).)).)))))))))))...........)))).))))))))))).)).)))).))))))))(((((((..((((((...((.((......)).))....))))))..))))))).))))))))))...)).)))))))))))...))))))))(((((.(((((((((((((((...........)))))))))).............((((......(((((((((........)))))))))...))))..))).)).)).)))...(((((((((((....(((((((((((.......((((((((((((....))).)).)))))))....))))))))))).)))))))))))...))))..)))).)))..
Thermodynamic Ensemble Prediction
..{{((((((((((((((.(.((((((((((.{,(((.((((((((((({{((...{,(((((((.((((((((((((,,(.((((((............)))))).))))))(((((.((((.((((....).)))...)))).)))))....)))))))).))))))).)...))}..}))))))...((((((...,((((((....)))))))|...}}}..},,.))))))......})..))),))).))))))))))).))))))))}).))))).)}.(((.(((((((((((({,(((...((((((.(((((.((.(((({..(((((,((((,.(((((..,.,((((((((((((({...,))).)))).{{(..(((((((({......))))....}})}}..))}))))))((((((((.,(((,({{{.((((({......,....((((((..(((((....)))))..))))))((((((((.((((((.(((((((,,(((((((,,{{(((({....,,,)||||,.,||......((.(((((((((((,((,({((((((((.((((........)))).))))}}{((.....}}}(((..(((....)))..)))}))))))).}}.))))))))))),,..,,,....)))).))))))))))).)},)))).))))))))||{|{,|,,|||}})))))))}}}}.))),,..)))))))).)))))}))).,.))))))))))...)).)))))))))))...))))))))||{{{,{(((({{((((((((.,,......,,))))))))}}.........,,,,({((......(((((((((........)))))))))...}}},..))).)).))},}}.{{(((((((((((....{({,,(((((,.......(((((((,,(((....))).,,.)))))))....,)))))),))}.)))))))))))}..})))..}))).)))..

Transcripts

ID Sequence Length GC content
NM_001257389.2 NCBI
AGACUAGGAUCCCUGGAAAAUGGAGAAGCUGUGCUAAUAGAGGGGGGCC… 1358 nt 0.5353
NM_001257390.2 NCBI
GUUGGGCUGAAGACCGUUUCUCCAGGCUGGGUGUUGGGUGGGGAAAGGG… 1157 nt 0.5436
NM_001257391.2 NCBI
AGGCCCGGCAGCCAUGGCGGUGGAAGGAGGAAUGAAAUGUGUGAAGUUC… 968 nt 0.5072
NM_001257392.1 NCBI
GCCCGGCAGCCAUGGCGGUGGAAGGAGGAAUGAAAUGUGUGAAGUUCUU… 777 nt 0.5045
NM_001257400.2 NCBI
GCCCCUCUCCCCCUUUCCCUCCUCCCAGCGCUUGGGGGCCUGUGCAGUG… 926 nt 0.5108
NM_001257401.2 NCBI
AAUUUGCUCCUGCCCUGGGCUCCUGGCUUGAGAGGCUACUGUUUGUCUA… 1117 nt 0.5121
NM_001267698.2 NCBI
AGAGAGCCCCGGAGCCGCGGCGGGAGAGGAACGCGCAGCCAGCCUUGGG… 1180 nt 0.5492
NM_001413281.1 NCBI
AGACUAGGAUCCCUGGAAAAUGGAGAAGCUGUGCUAAUAGAGGGGGGCC… 1029 nt 0.5306
NM_001413282.1 NCBI
AGUGGGGCCGAGGCUGGAGGUGUGGGGGUGUGACGGCCGGUCCUACUCU… 1115 nt 0.5498
NM_001413283.1 NCBI
AGACUAGGAUCCCUGGAAAAUGGAGAAGCUGUGCUAAUAGAGGGGGGCC… 1122 nt 0.5348
Showing 1 to 10 of 16 entries
Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Forensic Context

A study in mice demonstrated that exosomes isolated from serum after total-body irradiation exacerbated intestinal injury by promoting apoptosis and DNA damage, as indicated by increased markers including the CD63 [Li et al. DOI:10.1038/s41401-021-00615-6]. In human forensic research, the CD63 was validated as a stable exosomal surface marker, showing no significant difference in expression between exosomes isolated from post-mortem body fluids and those from ante-mortem controls, and its expression was sustained under simulated post-mortem conditions for up to 48 hours [Kim et al. DOI:10.3390/diagnostics12092153].