Basic Information

Symbol
CCL4L2
RNA class
mRNA
Alias
C-C Motif Chemokine Ligand 4 Like 2 Monocyte Adherence-Induced Protein 5-Alpha Macrophage Inflammatory Protein 1-Beta Chemokine (C-C Motif) Ligand 4-Like 2 C-C Motif Chemokine 4-Like MIP-1-Beta CCL4L Lymphocyte Activation Gene 1 Protein Macrophage Inflammatory Protein-1b2 Small-Inducible Cytokine A4-Like AT744.2 SCYQ4L2 SCYA4L1 SCYA4L2 SCYA4L LAG-1 LAG1
Location (GRCh38)
17:36210924-36212878
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001291468.2
Sequence length
647.0 nt
GC content
0.4807

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-194.20 kcal/mol
Thermodynamic ensemble
Free energy: -205.83 kcal/mol
Frequency: 0.0000
Diversity: 153.66
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((((........)))))).(((..((.(((((..((((((((....))))......((((.........((((((((((......(.(((......))).).....(((((((.(((........)))..)))))))...(((((....((((..........)))).....))))).............(((((((....)))))))..)))))))))).........))))...((((.((.((((.((.((((....)))).))..)))))).))))))))..(((((......)))))((((((.(((....)))..))))))...))))).))..))).(((((((((((.(.....(((.(((...((((((..(((((((..(((...)))..))).....))))..))))))...))).)))..).))))))))))).......((((((......))))))((((.((((.((((...((((.......))))...)))).)))).))))....((((...(((((((...)))))))))))................(((....)))((((((((((((((...))))..)))))))))).........................)))...
Thermodynamic Ensemble Prediction
.(((((((((.(((..{((({..,.|||}||||.||}}||{{({{{{,....}|||,........,,|,...,,.,{{{{{|{{{,...,.{.(((......))).,.....(((((((.(((........)))..)))))))...{((({....{(((,..,,.....}}}}..},.))))).............(((((((....)))))))..}}}}}}))}|((((((..{((((..(((((,,{{,|,,{{({({,,{{{{,||{,||{..{{{.,,,}))))),}}|,|||}..,..)))))((((((.(((....)))..))))))......,.}))))))).(((((((((((.,,,.,.(((.(((...((((((..(((((((..(((...)))..))),....})))..))))))...))),))},.),))))))))))).,)),},..))))))}...,..{(.((((.((((.((((...((((.......)))}...)))).)))).)))))}.|(({,...{((((((...))))))}}}}}......,....,,,,.,||},.,|}{((((((((((((((...))))..))))))))))}.,,.....................}))...

Transcripts

ID Sequence Length GC content
NM_001291468.2 NCBI
AGCACAGGACACAGCUAGGUUCUGAAGCUUCUGAGUUCUGCAGCCUCAC… 647 nt 0.4807
NM_001291469.2 NCBI
AGCACAGGACACAGCUAGGUUCUGAAGCUUCUGAGUUCUGCAGCCUCAC… 851 nt 0.4912
NM_001291470.2 NCBI
AGCACAGGACACAGCUAGGUUCUGAAGCUUCUGAGUUCUGCAGCCUCAC… 1253 nt 0.5116
NM_001291471.2 NCBI
AGCACAGGACACAGCUAGGUUCUGAAGCUUCUGAGUUCUGCAGCCUCAC… 831 nt 0.4922
NM_001291472.2 NCBI
AGCACAGGACACAGCUAGGUUCUGAAGCUUCUGAGUUCUGCAGCCUCAC… 810 nt 0.4914
NM_001291473.2 NCBI
AGCACAGGACACAGCUAGGUUCUGAAGCUUCUGAGUUCUGCAGCCUCAC… 780 nt 0.4859
NM_001291474.2 NCBI
AGCACAGGACACAGCUAGGUUCUGAAGCUUCUGAGUUCUGCAGCCUCAC… 736 nt 0.4783
NM_001291475.2 NCBI
AGCACAGGACACAGCUAGGUUCUGAAGCUUCUGAGUUCUGCAGCCUCAC… 841 nt 0.4923
Summary

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]

Forensic Context

A study in human trauma patients demonstrated that the CCL4L2 mRNA was significantly downregulated in circulating T cells during the injury stage compared to the recovery stage and was involved in the chemokine signaling pathway [Rau et al. DOI:10.2147/JIR.S375881].